Xerese Coupon & Discounts

Save on Xerese at your pharmacy with the free discount below.

Xerese may be prescribed to adults and children ages 6 and older to alleviate cold sores on the lips and mouth. It comes as a topical cream, and a 5g tube of this cream typically costs $500 or more if the medication is not covered under an insurance plan. Before paying the full Xerese cost out of pocket, check to see if you can use a FamilyWize coupon or discount card at your pharmacy. Our Xerese coupon is accepted at most pharmacies and can save you as much as 52% on the Xerese retail price. Click ‘Claim Discount’ to print or download this coupon now, or click ‘Free Card’ to have us mail you a Xerese discount card that can help you save on this and over 50,000 other qualifying medications.

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About Xerese

What is Xerese?

The Xerese cream contains two drugs: acyclovir and hydrocortisone. This medication helps reduce the pain and size of cold sores, as well as the time it takes the cold sores to heal. It is not, however, a complete cure for cold sores caused by the herpes virus.

How do I use Xerese?

Use Xerese exactly as your doctor tells you to. This topical medication is usually applied five times a day for five days starting at the first sign of a cold sore. Apply the Xerese cream over the entire affected area, but do not rub in or cover with a bandage. If your cold sores have not improved after two weeks of treatment, talk to your doctor.

What if I forget to take a dose of Xerese?

Apply Xerese as often as your doctor tells you to in order for it to be most effective. If you forget an application, apply it as soon as you remember. Do not apply more of the Xerese cream than you normally would in an effort to catch up.

What happens if I overdose on Xerese?

Overdosing on Xerese through topical application is highly unlikely. However, if you or anyone in your household swallows some of this ointment, call Poison Control at 1-800-222-1222 immediately.

Before using Xerese, tell your doctor if:

  • You are allergic to acyclovir, hydrocortisone, or any of the inactive ingredients in this medication (your doctor should have a list)

  • You have any other allergies

  • You are taking any other prescription or non-prescription medications or supplements

  • You have a weakened immune system

  • You are breastfeeding, pregnant, or trying to become pregnant

What are the possible side effects of taking Xerese?

Irritation at the application site is one of the most common side effects of Xerese. If you experience any skin drying, swelling, flaking, redness, or discoloration that persists or worsens, tell your doctor. Serious side effects are rare, but if you do have any other unusual or bothersome side effects, let your doctor know right away.

How do I store Xerese?

Keep Xerese in its original container, tightly sealed and out of reach of any children or pets in your home. Store at room temperature, ideally between 68 and 77 degrees. Do not freeze this medication under any circumstances. If you no longer need this topical medication or it has expired, ask your pharmacist how to properly dispose of it.


Xerese is intended for external use on the lips and mouth only and should not be used inside the eyes, nose, or mouth. This medication should not be prescribed to children under the age of 6.

Brand Name

There is currently no generic equivalent to Xerese. If you need this brand name drug but are concerned about paying for it out of pocket, get a reusable Xerese coupon and start saving as much as 52% on each prescription fill.


“I have been able to afford and purchase my prescribed medications for prices much better than using my insurance. I am trying to understand how that is possible. Anyway, I highly recommend”

- Sarah Proctor - Austin, TX

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