WARNING: This medicine combined with estrogen should not be used to prevent heart disease, heart attacks, strokes, or dementia. Progestin hormones combined with estrogen may increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, in the lungs or legs), and breast cancer in some women. Talk with your doctor if you have questions about the benefits and risks of using this medicine. THIS MEDICINE SHOULD BE USED FOR THE SHORTEST POSSIBLE TIME at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use this medicine. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking aprepitant or rifamycins (eg, rifampin). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including a history of asthma, the blood disease porphyria, mental or mood problems (eg, depression), diabetes, eye or vision problems, fluid retention or swelling (edema), gallbladder or pancreas problems, heart problems, high blood pressure, stroke or bleeding in the brain, high cholesterol or triglyceride levels, kidney problems, high or low blood calcium levels, lupus, migraines, seizures (eg, epilepsy), thyroid problems, abnormal mammogram or breast lumps, endometriosis, ovarian cancer, yellowing of the eyes or skin during pregnancy or with past estrogen use, allergies, pregnancy, or breast-feeding. Tell your doctor if a family member has a history of breast cancer or blood clots (eg, in the legs or lungs).Tell your doctor if you smoke, use tobacco products, are very overweight, have had a miscarriage, or have had your uterus removed (hysterectomy). Tell your doctor if you will be having surgery or will be confined to a bed or chair for a period of time. USE OF THIS MEDICINE IS NOT RECOMMENDED if you are pregnant, suspect you may be pregnant, or if this medicine is being used to test for pregnancy. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have undiagnosed abnormal vaginal bleeding; blood clots (eg, in the lungs or legs); known or suspected breast cancer or other estrogen- or progesterone-dependent cancer; liver disease; or a history of breast cancer, blood clots, or liver problems. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have had a heart attack or stroke within the past 12 months. Use of this medicine in children is not recommended. Discuss with your doctor the risks and benefits of giving this medicine to your child. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.