WARNING: This medicine is similar to certain antidepressant medicines. Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using this medicine outweigh the risks. Families and caregivers must closely watch patients who take this medicine. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor. THIS MEDICINE IS NOT APPROVED FOR USE in children or to treat depression. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days. DO NOT TAKE THIS MEDICINE IF you are taking tryptophan, a selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine), or another SNRI (eg, duloxetine). ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking a 5-HT1 receptor agonist (eg, sumatriptan), lithium, rasagiline, St. John's wort, tramadol, a diuretic (eg, furosemide, hydrochlorothiazide), an anticoagulant (eg, warfarin), aspirin, a non-steroidal anti-inflammatory drug (NSAIDS) (eg, ibuprofen), digoxin, epinephrine, norepinephrine, or clonidine. IF YOU ARE BEING SWITCHED TO THIS MEDICINE AFTER TAKING another medicine called clomipramine, you may have an increased risk for certain side effects (eg, dizziness or lightheadedness upon standing, exaggerated sense of well-being). Contact your doctor if any of these symptoms occur. IF YOUR DOCTOR TELLS YOU TO STOP taking this medicine, you will need to wait for at least 5 days before beginning to take certain other medicines (eg, MAOIs). Ask your doctor when you should start to take your new medicines after you have stopped taking this medicine. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of seizures, heart problems (eg, heart failure, irregular heartbeat), recent heart attack, high blood pressure, bleeding problems, kidney problems, liver problems, urinary blockage or trouble urinating, enlarged prostate, increased eye pressure (eg, glaucoma); allergies (including tartrazine); pregnancy; or breast-feeding. Tell your doctor if you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse. Tell your doctor if you are dehydrated, have low blood sodium levels, or drink alcohol. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have uncontrolled narrow-angle glaucoma or end-stage kidney disease. This medicine should not be used in CHILDREN younger than 17 years old; safety and effectiveness in these children have not been confirmed. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.