WARNING: THIS MEDICINE IS A NONSTEROIDAL ANTI-INFLAMMATORY DRUG (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you use this medicine for a long time. DO NOT USE THIS MEDICINE right before or after bypass heart surgery. THIS MEDICINE MAY CAUSE AN INCREASED RISK of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking disulfiram, or metronidazole. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), direct factor XA inhibitors (eg, rivaroxaban), heparin, prasugrel, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), azole antifungals (eg, itraconazole, voriconazole), bisphosphonates (eg, risedronate), probenecid, rifamycins (eg, rifampin), cyclosporine, lithium, methotrexate, oral NSAIDs (eg, ibuprofen), quinolones (eg, ciprofloxacin), tenofovir, angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), diuretics (eg, furosemide, hydrochlorothiazide), medicines that may harm the liver (eg, acetaminophen, ketoconazole, isoniazid, certain medicines for HIV infection, certain antibiotics or seizure medicines), or furazolidone. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor if you drink alcohol or if you have any other medical conditions including existing skin infection or irritated, broken skin on the knee area, poor health, dehydration or low fluid volume, low blood sodium levels, allergies (especially aspirin or NSAID allergy), pregnancy, or breast-feeding. Tell your doctor if you have a history of alcohol abuse, swelling or fluid buildup, asthma, nasal polyps (growths in the nose), mouth inflammation, autoimmune problems such as lupus, liver or kidney problems, eye disease, diabetes, stomach or bowel problems (eg, bleeding, perforation, ulcers). Tell your doctor if you have high blood pressure, a blood disorder (eg, porphyria), bone marrow problems, heart problems (eg, heart failure), blood vessel disease, bleeding or clotting problems, or if you are at risk for any of these conditions. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have severe kidney disease, you are in the last 3 months of pregnancy, or you have recently had or will be having bypass heart surgery. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.