WARNING: This medicine must be administered in an appropriate medical setting. Serious allergic reactions, some fatal, have occurred with the use of this medicine. DO NOT use this medicine again if you have experienced a severe allergic reaction to it. Stop using this medicine and notify your doctor immediately if you develop signs of an allergic reaction, such as rash; itching; fainting; severe dizziness or light-headedness; swelling of hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness. CERTAIN PATIENTS with solid tumors or AIDS-related Kaposi sarcoma should not use this medicine. Frequent blood tests should be performed while you are using this medicine because of the risk of bone marrow suppression and serious infection. DO NOT SUBSTITUTE or interchange this medicine with other forms of paclitaxel. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you have taken or will be taking palifermin within 24 hours before or after using this medicine. ADDITIONAL MONITORING OF YOU DOSE OR CONDITION may be needed if you are taking anticoagulants (eg, warfarin), azole antifungals (eg, itraconazole, ketoconazole), benzodiazepines (eg, midazolam, triazolam), buspirone, carbamazepine, cimetidine, cisplatin, doxorubicin, efavirenz, eletriptan, felodipine, fluoxetine, gemfibrozil, HIV protease inhibitors (eg, indinavir, ritonavir), HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), macrolides (eg, clarithromycin, erythromycin), nefazodone, nevirapine, phenytoin, repaglinide, rifampin, rosiglitazone, sildenafil, or telithromycin. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a bacterial or viral infection, HIV infection, allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of heart attack or other heart problems (eg, irregular heartbeat), high or low blood pressure, liver or kidney problems, bone marrow problems, or blood problems (eg, low platelet or neutrophil counts). Tell your doctor if you are undergoing radiation therapy or if you have ever had an allergic reaction to an insect sting. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of extremely low white blood counts (eg, extremely low neutrophil counts), or if you have shingles (herpes zoster) or chickenpox. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.