Imipramine HCL Coupon & Discounts

Save on Imipramine HCL at your pharmacy with the free discount below.

Imipramine, a tricyclic antidepressant, is used to treat depression and bedwetting. To reduce the price of imipramine HCl in your local pharmacy, print our free coupons following the link below and save up to 78% off the when you buy your medication. Also sign up for a free discount card from FamilyWize to save on every refill of imipramine HCl. Follow the link to claim your free coupon now, or continue reading about this medication below.

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About Imipramine HCL

What is imipramine HCl?

Imipramine hydrochloride (HCl) is a tricyclic antidepressant that is used to treat major depressive disorder and childhood enuresis. Tricyclic antidepressants are named after their chemical structures which contain three rings of atoms. They are some of the oldest antidepressants on the market and have been largely replace by SSRIs. Imipramine affects several receptors including serotonin, dopamine, histamine, and acetylcholine, but it mainly works by inhibiting the reuptake of serotonin and norepinephrine. This increases the availability of these two neurotransmitters and provides an elevation in mood. Although imipramine is used to treat enuresis, or the inability to control urination, the way it works is not understood.

How do I take imipramine HCl?

Imipramine hydrochloride comes as a tablet or a capsule to be taken orally. The typical adult dosage for depression is 75mg once per day. Your doctor may slowly increase your dose over time to achieve the medication’s maximum benefit. Teenagers and senior adults should begin taking between 25 and 50mg per day. To treat enuresis, 25mg should be taken approximately one hour before bedtime. If your child is under six, follow your pediatrician’s instructions. Safety has not been established for this age group.

What if I forget to take a dose of imipramine HCl?

If you miss a dose of imipramine HCl, take the missed dose as soon as you remember it. If it’s almost time for your next dose, skip the missed dose and continue on your regular schedule. If you take imipramine for enuresis and you miss a dose before bed, do not take the dose the next morning. Skip the dose and wait until the next evening.

What happens if I overdose on imipramine HCl?

Signs of overdose on imipramine HCl include severely low blood pressure, irregular heartbeat, tachycardia, drowsiness, hyperactive reflexes, convulsions, decreased breathing, vomiting, and dilated pupils. Imipramine overdose can be fatal, especially when mixed with other substances like alcohol. If you think you or someone you know has overdosed on imipramine, contact the Poison Control Center at 1-800-222-1222. If the victim is in a coma or unresponsive, call 911.

Before taking imipramine HCl, tell your doctor if:

  • You have symptoms of bipolar disorder.

  • You have ever had a heart attack.

  • You have kidney, liver, heart disease, or high blood pressure.

  • You have hyperthyroidism.

  • You have ever had suicidal thoughts or attempted suicide.

  • You have schizophrenia or any other mental illness.

  • You are pregnant or breastfeeding.

  • You have ever had glaucoma or urinary retention problems.

  • You have a history of seizures.

  • You have diabetes.

  • You smoke cigarettes or drink alcohol regularly.

  • You are taking other prescription or nonprescription drugs, vitamins, or supplements, especially other antidepressants, medications for mental conditions, medications for GERD or acid reflux, medications for irregular heartbeat, clonidine, guanethidine, St. John’s wort, and medications containing methylene blue.

  • You are allergic to medications similar to imipramine or any of the ingredients in this medication.

What are the possible side effects of taking imipramine HCl?

Possible side effects from taking imipramine HCl include dizziness, drowsiness, dry mouth, gastric distress, constipation, nausea, blurred vision, headache, increased heart rate, decreased libido, loss of appetite, and a strange taste in the mouth. Less common but more serious side effects include confusion, hallucinations, pounding heartbeat, problems with speech or balance, rapid weight gain, severe headache, seizures, shortness of breath, swelling, sudden weakness or numbness, a worsening of depression, and a change in urination patterns. Contact your doctor immediately if you experience any serious side effects.

How do I store imipramine HCl?

Store imipramine HCl in an airtight container at a room temperature between 68 and 77 degrees Fahrenheit. Protect your medication from light and moisture and keep it out of reach of children and pets.


Imipramine HCl and other antidepressants pose a risk for an increased chance of suicide among children and young adults. Monitor for signs of aggression, indications of suicidal thoughts, or a worsening of the condition. Report any of these signs to your prescribing doctor at once. Alcohol may increase the chances of dangerous side effects from imipramine. To decrease the dizziness that may accompany this medication, get up slowly from a reclining position and avoid overheating.

Brand Names

Brand names for imipramine HCl include Tofranil. To reduce the price of this medication in your local pharmacy by up to 87%, use our printable imipramine coupons or sign up for a free discount card from FamilyWize. Also search for Tofranil and save up to 75% off the price.


“I have been able to afford and purchase my prescribed medications for prices much better than using my insurance. I am trying to understand how that is possible. Anyway, I highly recommend”

- Sarah Proctor - Austin, TX

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