WARNING: Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using this medicine outweigh the risks. ALTHOUGH THIS MEDICINE IS NOT USED TO HELP PATIENTS STOP SMOKING, another brand of medicine that contains bupropion is approved for this use. Serious mental or mood problems, including depression and suicidal thoughts or actions have been reported in some patients using bupropion to help them stop smoking. FAMILY AND CAREGIVERS MUST CLOSELY WATCH patients who take this medicine. It is important to keep in close contact with the patient's doctor. Contact the doctor at once if new, worsened, or sudden symptoms such as agitation; hostility; depressed mood; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur. Discuss any questions with the patient's doctor. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking another medicine that contains bupropion or if you are taking or have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking amantadine, antiarrhythmics (eg, propafenone, flecainide), antimalarials, (eg, mefloquine), antipsychotics (eg, haloperidol, risperidone), beta-blockers (eg, metoprolol), carbamazepine, clopidogrel, corticosteroids (eg, prednisone), cyclophosphamide, efavirenz, insulin, levodopa, lithium, lorcaserin, methylene blue, nicotine replacement therapy (eg, nicotine patches), oral hypoglycemics (eg, glipizide), orphenadrine, phenobarbital, phenothiazines (eg, thioridazine), phenytoin, pimozide, quinolone antibiotics (eg, levofloxacin), rifamycins (eg, rifampin), ritonavir, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), sympathomimetics (eg, pseudoephedrine), tamoxifen, theophylline, thiotepa, tiagabine, ticlopidine, tricyclic antidepressants (eg, nortriptyline), or other antidepressants (eg, venlafaxine). Tell your doctor if you are taking nonprescription weight loss medicines or stimulants. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including diabetes, kidney problems, liver problems (eg, cirrhosis), high blood pressure, heart problems (eg, congestive heart failure), recent heart attack, allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of a head injury or a tumor in the brain or spinal cord. Tell your doctor if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse. Tell your doctor if you drink alcohol. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy). USE OF THIS MEDICINE IS NOT RECOMMENDED if you are suddenly stopping the use of alcohol, sedatives (medicines that make you sleepy), or benzodiazepines (eg, alprazolam) after long-term use. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.